Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland at Baltimore, Baltimore, MD 21201, USA
Short Communication
Delivering a Brand-new Triple Drug Combination over and over again for Improved Breast Cancer Treatment.
Author(s): Huan Ming*
Although breast cancer is still a major worldwide health concern, new, promising
therapeutic options are now available because to the development of carefully
considered medication combinations and sophisticated biocompatible delivery
methods. Based on the selective tumour apoptotic impact of Rosuvastatin (RST),
we repurposed it here and coupled it with the antimetabolite pemetrexed (PMT)
and the tumor-sensitizing polyphenol honokiol (HK). Inspired by the stealth feature
of sodium alginate (ALG) and the cancer cell targeting ability of Lactoferrin (LF),
this synergistic three-drug combination was combined into protein polysaccharide
Nano hybrids. ALG was conjugated to PMT, combined with LF, which was
conjugated to RST, and then inserted physically into core shell Nano hybrids made
of genipin and LF.
The PMT-ALG/LF-RST Nano hybrids with cross-link.. View More»
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