Journal of Biomedical Sciences

  • ISSN: 2254-609X
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Jim scarlet

INSERM U624, Stress Cellulaire, Parc Scientifique et Technologies de Luminy, 163 Avenue de Luminy, BP 915ΒΈ13288 Marseille cedex 9, France

  • Mini Review   
    Malignancy Oxidative Shift Stimulated by Lack of Oxygen relates to Tumor Aggressive behaviors
    Author(s): Jim scarlet*

    With a 5-year survival rate of only 3?5%, pancreatic ductal adenocarcinoma remains one of the most lethal solid tumours. A typical clinical presentation of an incurable disease is the result of its aggressive biology and resistance to conventional and targeted therapeutic agents once it is diagnosed. Desmoplasia, a dense stroma of fibroblasts and inflammatory cells, is the hallmark of the disease. It prevents oxygen from reaching the organ and creates a strong hypoxic environment within the tumor. We argue in this review that pancreatic cancer cells undergo oncogenic and metabolic changes, facilitating their proliferation, and that hypoxia is to blame for the tumour?s highly aggressive and metastatic characteristics. However, the molecular changes that cause pancreatic cancer cells to adapt their metabolism remain a mystery. Cachexia is a symptom of this illness that shows that.. Read More»

    DOI: 10.36648/2254-609X-12.01-91

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