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International Journal of Drug Development and Research

  • ISSN: 0975-9344
  • Journal h-index: 49
  • Journal CiteScore: 11.20
  • Journal Impact Factor: 8.24
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
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Katie Uhl

Department of Cell and Molecular Biology, School of Graduate Studies, Grand Valley State University, Allendale, MI, USA

Publications
  • Research Article   
    Qualitative Analysis of the Biological Testing of Novel Telomerase Inhibitors
    Author(s): Suganthi Sridhar*, Katie Uhl, Basma Khudur, Bikash Mishra, Robert Smart and William Schroeder

    Cancer is often referred to as being “immortal” because of high telomerase activity in these cells, which allows them to divide an infinite amount of times. BIBR-1532, (2-{[(2E)-3-(2Naphthyl)-2-butenoyl]amino}benzoic acid) is a known telomerase inhibitor that has undergone preclinical trials for the treatment of cancer. Based on the structure of BIBR-1532, three novel N- cinnamoyl substituted anthranilic acid derivatives (2-{[(2E)-3-(4 “ X ” phenyl)-2- propenoyl]amino}benzoic acids), similar to BIBR-1532 were synthesized. Their efficacies were tested against proliferative activity in metastatic prostate cancer cells, along with the known telomerase inhibitor BIBR-1532. Telomerase Repeat Amplification Protocol (TRAP) assays were performed on the compounds to confirm their antitelomerase activity. The results showed all three newly synthesized cinnamic derivative.. View More»

    Abstract PDF