Department of medical science and pharmacology sciences, United States
Short Communication
On Transdermal Pharmacology and Toxicology.
Author(s): Lynne Abbeye
Objective: To evaluate the underlying pharmacology, safety, and misuse/abuse of
transdermal fentanyl, one of the cornerstone pharmacotherapies for patients with
chronic pain.
Methods: Literature was identified through searches of Medline (PubMed) and
several textbooks in the areas of pharmacology, toxicology, and pain management.
A bibliographical review of articles identified by these searches was also performed.
Search terms included combinations of the following: fentanyl, transdermal,
patch, pharmacology, kinetics, toxicity, and poisoning. All pertinent clinical trials,
retrospective studies, and case reports relevant to fentanyl pharmacology and
transdermal fentanyl administered by any route and published in English were
identified. Each was reviewed for data regarding the clinical pharmacology,
abuse, misuse.. View More»