Department of Orthopaedics, University of Sydney, Australia
Mini Review
Mechanisms, Current Methods and
Future Prospects of Biomimetic Surface
Functionalization for Bone-Integrating
Orthopaedic Implants
Author(s): Moraes Marilia*
The incidence of orthopaedic implants is rising worldwide, with hundreds of
thousands of surgeries performed each year. However, due to inadequate bone
integration, a sizeable fraction of these surgeries fail. Numerous research directions
have been looked at to address this problem and enhance the biocompatibility
of orthopaedic devices by altering the body's reaction to the implant surface.
Orthopedic surfaces with biomimetic functionalization can signal through
immobilised proteins and other biomolecules to influence the biological response.
By encouraging osteoblast development and bone growth at the implant surface,
this strategy hopes to integrate the orthopaedic surface with the surrounding
bone tissue. The requirement for biomimetic functionalization is first highlighted
in this review from a materials and biological standpoint. the characteristics.. View More»
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