Department of Medical Oncology, VU University Medical Center, Amsterdam UMC, Amsterdam, Netherlands
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Lactate and Succinate, Oncometabolites, Activate Pro-Angiogenic Macrophages in Malignancies.
Author(s): Nicola Rocco*
Macrophages area unit innate vegetative cell leukocytes that area unit extremely gift in solid tumors, wherever they're brought up as tumor-associated macrophages (TAMs). In solid tumors, the microenvironment is commonly immunological disorder and hypoxic regions area unit current. These hypoxic conditions impose growth cells to reprogram their metabolism, shifting from organic process to anaerobic metabolic process. This alleged glycolytic switch permits hypoxic growth cells to survive, proliferate, and eventually to out compete untransformed cells. The hypoxia-induced modification in growth cell metabolism results in the assembly of oncometabolites, among t.. View More»
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