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Journal of Biomedical Sciences

  • ISSN: 2254-609X
  • Journal h-index: 18
  • Journal CiteScore: 4.95
  • Journal Impact Factor: 4.78
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
Google Scholar citation report
Citations : 1283

Journal of Biomedical Sciences received 1283 citations as per Google Scholar report

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Pattaya Seeree

Mahidol University, Thailand

Publications

  • Short Communication   
    Role of cholesterol transporters, ABCA1 and ABCG1 in cholangiocarcinoma
    Author(s): Pattaya Seeree*

    Statement of the Problem & Purpose: Epidemiology of cholangiocarcinoma (CCA) is high in Thailand and Southeast Asia. It is highly aggressive and poorly studied. In this investigation, the role of cholesterol transporters, ATP-binding cassette (ABC) A1 and ABCG1 are studied in HuCCA-1 cell line. ABCA1 and ABCG1 transporters are suspected to play a role in CCA lipid homeostasis. Methodology: The expression and localization of ABCA1 and ABCG1 were investigated by western blot analysis and immunocytochemistry, respectively. The functions of ABCA1 and ABCG1 in CCA cells were examined out by cholesterol efflux assay to specific cholesterol acceptor and high-density lipoprotein (HDL). ABCG1 transporter was down regulated using siRNA interference. Cell phenotypic changes such as cell migration and cholesterol export ability were observed by woun.. View More»

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