Division of Infectious Diseases, Department of Medicine, Vanderbilt University School of Medicine, Nashville, USA
Opinion
Immunopathogenesis and co-morbidities of Tuberculosis
Author(s): Paul Timothy*
The etiologic agent of Tuberculosis (TB), Mycobacterium tuberculosis, continues to pose a serious threat to worldwide public health. Globally, 10.4 million new TB cases were recorded in 2016, and there were around 1.7 million TBrelated fatalities. One of the most important aspects of attempts to eliminate TB through the creation of potent vaccines and immunological treatments understands the host response to M. tuberculosis infection. An intracellular infection called M. tuberculosis spreads by the inhalation of aerosolized droplets carrying germs. The lungs' innate immune cells, particularly macrophages, dendritic cells, monocytes, and neutrophils, constitute the first line of defence against M. tuberculosis.
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