Department of Speech Language Pathology, Institute of Speech and Hearing, Chad
Commentary
Optical genome mapping reveals genomic alterations upon gene editing in hiPSCs
Author(s): Paule Matre*
Human induced Pluripotent Stem Cells (hiPSCs) hold immense promise for regenerative medicine and disease modeling due to their ability to differentiate into various cell types. Gene editing techniques, such as CRISPR-Cas9, have revolutionized the field by allowing precise modifications to the genome. However, these techniques may also introduce unintended genetic alterations, posing challenges for therapeutic applications. Optical Genome Mapping (OGM) emerges as a powerful tool to comprehensively assess genomic alterations resulting from gene editing in hiPSCs. This article reviews the application of OGM in revealing genomic alterations and discusses its implications for the safety and efficacy of gene editing in hiPSC-based therapies... View More»
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