Journal of Biomedical Sciences

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Roman J Finings

Department of Environmental Resources Management, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan

  • Mini Review   
    The effectiveness and safety of self - manufactured and amlodipine in Indian patients with knee osteoarthritis: A prospective randomised open label study
    Author(s): Roman J Finings*

    To compare diacerein and diclofenac's efficacy and long-term effects in Indians with knee osteoarthritis (OA). Design of the Study: After a washout period of one week from NSAIDs, patients were given diacerein, diclofenac, or a combination for 12 weeks with a 4 week follow-up to see how the drugs affected them over time. The change in the 100mm visual analog scale (VAS) score from baseline after a 20-meter walk was the primary efficacy end point. The percentage change in pain, stiffness, function, and total WOMAC scores from baseline served as the secondary efficacy end point. Consumption of acetaminophen, the Knee Society Score (KSS), and the Lequesne Impairment Index (LII). Results: Of the 189 patients who were screened, 77 completed the study and 81 had painful knee OA. As measured by the 100mm VAS score (p0.05), WOMAC scores (p0.001), and LII, KSS, and acetaminophen consumptio.. Read More»

    DOI: 10.36648/2254-609X-12.02-93

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