Molecular Enzymology and Drug Targets

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Santu Singh

Department of Microbiology, University of Delhi, India

  • Mini Review   
    Exploring the Role of Glycolysis in Cancer Metabolism: Implications for Targeted Therapies
    Author(s): Santu Singh*

    Cancer metabolism has emerged as a key player in tumorigenesis and tumor progression, with altered metabolic pathways driving oncogenesis and supporting the high energy demands of cancer cells. Among these pathways, glycolysis, a process that converts glucose to pyruvate, plays a crucial role in providing ATP and biosynthetic intermediates for rapidly proliferating cancer cells. In this review, we explore the intricate interplay between glycolysis and cancer metabolism, focusing on how deregulation of glycolytic enzymes and transporters contributes to tumor growth and survival. Moreover, we delve into the underlying molecular mechanisms that promote the Warburg effect, a hallmark feature of cancer cells characterized by enhanced glycolysis even under normoxic conditions. Understanding these metabolic adaptations is essential for identifying potentia.. View More»

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