Lugansk State Medical University Luhansk Oblast, 93000, Ukraine
Review
β-Amyloid peptide and the Alzheimer’s disease
Author(s): Tshetiz Dahal*
The formation and deposition of the -amyloid peptide (A) are largely
thought to be responsible for the development of Alzheimer's
disease (AD). Researchers have been perplexed by the sluggish to
nonexistent association between the degree of clinical dementia
and the amount of neuritic plaque disease in the human brain
for a long time. This question has been resolved thanks to recent
developments in our knowledge of the origins of amyloid disease.
The solubility of A and the amount of A in various pools may now
be more directly tied to disease state, according to substantial
evidence. The make-up of these pools of A reflects various
populations of amyloid deposits and is clearly correlated with the
patient's clinical condition. Using imaging methods, such as novel
amyloid imaging agents based on the chemical makeup of histology
dyes, .. View More»
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