General Physician, Clinical Researcher and Writer, Lugansk State Medical University, Luhansk Oblast, 93000 Luhansk, Ukraine
Research
Assessment of Neoantigen-Related Somatic Mutations in Non-Small Cell Lung Cancer
Author(s): Tshetiz Dahal*
Aim: The aim of this study is to examine the efficacy and safety of immune checkpoint inhibitors (ICIs) as a treatment for advanced nonsmall cell lung cancer (NSCLC). Neo-antigens are significant biomarkers and possible therapeutic targets that are crucial for the diagnosis and care of NSCLC patients. In materials from patients who had surgical therapy for NSCLC, this study sought to assess and define the connections between somatic mutations and possible neoantigens.
Patients and methods: This prospective study examined tissue samples from NSCLC patients who received surgery for their condition. Both tumour tissues and matched normal tissues underwent whole-exome sequencing. Using generative software, candidate neoantigens were predicted, and the associations between different mutational features and the quantity of neoantigens were assesse.. View More»
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