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International Journal of Drug Development and Research

  • ISSN: 0975-9344
  • Journal h-index: 49
  • Journal CiteScore: 11.20
  • Journal Impact Factor: 8.24
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
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Vikas Jain

Mahakal Institute of Pharmaceutical Studies, Behind Air Strip, Datana, Dewas Road, Ujjain, Madhya Pradesh 456664, India

Publications
  • Mini Review   
    Novel Nano-Based Drug Delivery Systems for Fibrotic Liver's Hepatic Stellate Cells
    Author(s): Vikas Jain*

    Hepatic stellate cells (HSCs) are phenotypically active and develop a phenotype resembling myofibroblasts in the perisinusoidal region of the liver. Affected hepatic function, portal hypertension, increased vascular resistance; fibrosis, cirrhosis, and hepatocellular carcinoma are all results of this phenotypic transformation, which is also responsible for the accumulation and production of various extracellular matrix (ECM) proteins in the perisinusoidal space. In the injured liver, the main collagen-producing cells are activated HSCs/myofibroblasts. As a result, HSCs are frequently the focus of fibrosis treatments. Since HSCs contain the majority of the body's retinol, antifibrotic nanomedicine frequently target them with vitamin A decorating. Transforming growth factor-beta, collagen, and connective tissue growth factors are targeted by vitamin A-decor.. View More»

    DOI: 10.36648-0975-9344-15.1-991

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