Department of Biology and Geology, Preparatory Institute to Engeneiring Study, Sfax, Tunisia
Review Article
What are the Different Cross Talks between HIF1-?, TGF?, Integrin and ECM in Mediating Breast Cancer?
Author(s): Sami Baccoche*, Nejla Fourati, Wissem Siala, Rachid Jlidi and Jamel Daoud
Extracellular Matrices (ECM) serve as the molecular scaffold for cell adhesion, migration, proliferation and differentiation and as a repository of cytokines and molecular cues that determine cell polarization and tissue organization. The EMC alteration conducts to Integrin β3 regroupement, after its TGFβ induced overexpression; important tumorogenesis step that mediates an amplified integrin-Fak-Src signaling leading to aggressive tumor phenotype.
The upstream of these events is the accumulation of stress sensor protein, HIF-1α, which in involved in a constitutive active TGFβ overexpression, epigenetic landscape remodeling and sustaining a Smad2/3 signaling by supressing VHL expression. Together, allowed TGFβ late target genes expression such as: SNAIL, MMP, galectin, paxillin and integrinβ3; and at the same time TGFβ early genes repressi.. View More»
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