Department of Veterinary Pathology, College of Veterinary Medicine & Institute of Veterinary Science, Kangwon National University, Chuncheon 24341, Republic of Korea
Review Article
Potential for Mucosal Delivery of Bacillus
Subtilis Spore Vaccines Displaying
Immunogenic Protein on the Surface
Author(s): Yeonsu Oh*
Vaccines are the most effective measures to prevent infectious diseases, and most
of these infections occur through the mucous membranes that cover the surfaces of the
vital
organs of our body.Mucosal vaccination is, however, challenging. The numerous natural defense mechanisms at mucosal surfaces, including the
acidic and enzyme-rich environment and the thick and firm mucus layer make the
delivery of vaccines across these natural barriers challenging.
Probiotic-grade
B. subilis spores could be utilized by the surface display technology as a mucosal vaccine delivery system and simultaneously as an adjuvant for mucosal immunity for the following reasons:
1. B. subtilis spores are resistant at ambient temperatures but remain viable.
2. B. subtilis spores are safe enough for consumption by humans as food
components, probiotics, or therapeutics.. View More»
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