University of Nebraska Medical Center, USA
Short Communication
Nano-assembly of amyloid β peptide: Role of the hairpin fold
Author(s): Yuri L. Lyubchenko*
Statement of the Problem: Increasing evidence suggests that the self-assembly of amyloid β(Aβ) protein underlies the early onset of Alzheimer’s disease (AD). Given that small Aβ nanoassemblies (oligomers) are the most neurotoxic species, they have become the major target for the development of treatments and early diagnostic tools for AD. However, advances surrounding this are blocked by the lack of structure intrinsic to Aβ oligomers, as they are transient states of Aβ aggregation kinetics; making traditional structural approaches nonamenable. We have previously developed single-molecule approa dimers. Here, we extended our approaches to higher order oligomers. We hypothesized that the folding pattern of amyloid protein defines the aggregation pathway.
Methodology & Theoretical Orientation: In this study, .. View More»
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