Spanish Chinese Russian German French Japanese Portuguese Hindi Telugu Tamil
Flyer

Archives of Medicine

  • ISSN: 1989-5216
  • Journal h-index: 17
  • Journal CiteScore: 4.25
  • Journal Impact Factor: 3.58
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
PMC/PubMed Indexed Articles

Metabolic Effects of Androgen-associated Body Mass in Klinefelter Syndrome

Catching and Correcting Unreported, Under-Reported Accidents (Near-Misses) among Healthcare Provider in Thailand

Google Scholar citation report
Citations : 1259

Archives of Medicine received 1259 citations as per Google Scholar report

Flyer image
Archives of Medicine peer review process verified at publons
Flyer image
Indexed In
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • OCLC- WorldCat
  • Proquest Summons
  • Publons
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
  • Google Scholar
  • Secret Search Engine Labs
View More
Share This Page

Association between SIRT1 gene rs3758391, rs3740051 and rs12778366 polymorphisms and breast cancer risk in Egyptians

Joint Event on 36th International Conference on Psychiatry and Psychosomatic Medicine & 9th International Conference on Addiction Psychiatry & Mental Health & 25th International Conference on Advanced Clinical Res
September 16-17, 2019 Rome, Italy

Sherine M. Rizk, Nancy N. Shahin and Olfat G. Shaker

Cairo University, Egypt

Posters & Accepted Abstracts: Arch Med

Abstract:

Silent mating-type information regulator 2 homolog 1(SIRT1) gene expression have been reported to be associated with breast cancer. However, no studies exist on the role of SIRT1 gene polymorphism in breast cancer risk or prognosis. The present study aimed to assess the association between SIRT1 gene polymorphisms and breast cancer in Egyptians. Breast cancer patients exhibited elevated serum SIRT1 levels which varied among different tumor grades. SIRT1 rs3758391 and rs12778366 TT genotypes were more frequent, exhibited higher SIRT1 levels than CC and CT genotypes and were associated with histologic grade and lymph node status. SIRT1 rs12778366 TT genotype also correlated with negative estrogen receptor (ER) and progesterone receptor (PR) statuses. The T allele frequency for both SNPs was higher in breast cancer patients than in normal subjects. Combined GG and AG genotypes of rs3740051 were more frequent, showed higher serum SIRT1 levels than the AA genotype, and were associated with ER and PR expression. Furthermore, inheritance of the G allele was associated with breast cancer. In conclusion, rs3758391 and rs12778366 polymorphisms of SIRT1 gene are associated with breast cancer risk and prognosis in the Egyptian population.

PDF HTML