Flyer

Archives of Clinical Microbiology

  • ISSN: 1989-8436
  • Journal h-index: 19
  • Journal CiteScore: 6.52
  • Journal Impact Factor: 0.72
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
20+ Million Readerbase
Indexed In
  • Open J Gate
  • Genamics JournalSeek
  • The Global Impact Factor (GIF)
  • Open Archive Initiative
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • OCLC- WorldCat
  • Proquest Summons
  • Publons
  • MIAR
  • University Grants Commission
  • Geneva Foundation for Medical Education and Research
  • Google Scholar
  • Scimago Journal Ranking
  • Secret Search Engine Labs
  • ResearchGate
Share This Page

Bioinformatics: determination of gene expression profile for some human immune genes after infection with Ebola virus

EuroSciCon Conference on Microbiology & Virology
June 21-22, 2018 Paris, France

Abdulrhem T Al-Ghazal

University of Mosul, Iraq

Posters & Accepted Abstracts: Arch Clin Microbiol

Abstract:

Objectives: Ebola virus (EBOV), a member of the Filoviridae family, causes severe and often lethal hemorrhagic fever in humans and nonhuman primates. The infection with EBOV causes the release of proinflammatory cytokines and chemokines which may represent factors of the severity of the hemorrhagic shock. Determining the level of human mRNAs of immune inflammatory cytokines after EBOV infection is regarded as important aspect to understand the relationship between EBOV and its host at molecular level. Methods: Sixteen immune genes were subjected to this study using analysis of Real-time-reverse transcription PCR-array (RTPCR-array, SABioscience). Control genes were taken from previous studies to get the fold change of gene expression. Results: The results showed that all subjected genes were up regulated with different fold change (FC) (CCL20 CCL23,CCL3, CCL4, CCL5, CCL8, CCR2, CCR7, CXCL2, CXCL3, CXCL6, IFNA2, IL10, IL1A, IL1B and TNF) ranged between 52.1797 FC for CCL20 and 4.3032 FC for TNF. These results revealed that EBOV has severe impact on specific human immune inflammatory genes.