Journal of Neurology and Neuroscience

  • ISSN: 2171-6625
  • Journal h-index: 17
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  • Journal Impact Factor: 3.38
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Determining the Neurocognitive status and the functional ability of patients to screen for HIV-Associated Neurocognitive Disorder (HAND)

Joint Event on 28th International Conference on Neuroscience and Neurochemistry & 28th Euro-Global Neurologists Meeting
June 13-14, 2019 Barcelona, Spain

Ritika Agarwal

Chandra Laxmi Hospital, India

Posters & Accepted Abstracts: J Neurol Neurosci


Statement: The aim of the study was to assess neurocognitive status and functional ability of people living with HIV.

Method: The study enrolled 160 Patient living with HIV (PLHIV) (80 pre-ART and 80 On-ART) fulfilling the inclusion and exclusion criteria. Neurocognitive assessment and an assessment of Functional ability was done by using the Montreal Cognitive Assessment (MoCA) and Lawton and Brody IADL Scale respectively.

Results: The study population consisted of 75.6% males and 24.4% females with mean age of 44±10 years. All of the subjects were literate (61.2% subjects had received up to High school level education), 76.2% were married. The mean duration of HIV infection among ART naive PLHIV and those on ART was 2±1.33 years and 3±2.10 years respectively. Most of the study subjects had WHO Stage 1 disease (Pre-ART 92.5% & ART 83.75%). The mean CD4 count of the study population at study enrolment was 361.46 ±187.28 cells/mm3 (range 34 - 844 cells/mm3). Only 5% of subjects were found to have mild impairment in ADL with the most common affected domain being food preparation (50%). The overall prevalence of HAND in the study subjects was 52.5%. Of these, 47.5% had ANI and 5% had MND. In MoCA, the most frequently affected domains were Language (97.6%), visuospatial ability (92.9%) and memory (71.4%).

Conclusion: The prevalence of HAND is high among PLHIV in India and one in two PLHIV have neurocognitive dysfunction. The prevalence of HAND among Pre-ART subjects (i.e. ART naive) and those on ART is similar suggesting that neurocognitive impairment starts early in HIV infection. Older age (>40 years) and fewer years of formal education (

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