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Archives of Clinical Microbiology

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ER Stress involved in replication and pathogenesis of Dengue virus

3rd Euroscicon Conference on Virology
July 26, 2021 WEBINAR

Ghafoor Hammad, Jamil Anjum, Jamil Razia

Department of immunology and microbiology, School of Medicine, Southeast University, Nanjing, Jiangsu, 2100096, China.
Department of Animal Ecology, School of life science, Zhengzhou University, 100 Science Avenue, Zhengzhou, Henan, 450001, P. R. China
School of communication and information engineering Zhengzhou University, 100 Science Avenue, Zhengzhou, Henan, 450001, P. R. China

Scientific Tracks Abstracts: Arch Clin Microbiol

Abstract:

Dengue virus is a single standard positive RNA virus that responsible for developing mysterious dengue fever. Dengue virus (DENV) associated with endoplasmic reticulum for replication and assembling. ER Stress response generated due to the accumulation of unfolded proteins in the endoplasmic reticulum lumen and unfolded protein response (UPR). UPR significantly reduced dengue virus due to the involvement of three different branches having a role in cellular activity. Moreover, ER Stress responsible for the induction of autophagy response. Dengue virus-induced autophagy response which represents an inter-linked reaction for the virus replication and modification. We demonstrated that CHOP and IRE-JNK signaling pathways increased cell migration response with autophagy response with elevated expression level of dengue virus. ER Stress pathway interlinked with apoptosis. These findings suggest that the invitro trail represents the dengue virus titration level with symptoms development through connected with ER Stress and apoptosis pathway. The present study filled a gap between dengue virus-induced ER Stress autophagy and pathogenesis through the UPR signaling pathway. Keywords: Dengue virus, ER Stress, autophagy