Journal of Neurology and Neuroscience

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Fever in patients with spontaneous intracerebral hemorrhage: prevalence and outcomes

5th EuroSciCon Conference on Neurology & Neurological Disorders
March 04-05, 2019 | Amsterdam, Netherlands

Hazel Gaile T Barrozo, Debbie C Liquete and Ma Socorro F Sarfati

Baguio General Hospital and Medical Center, Philippines

Posters & Accepted Abstracts: J Neurol Neurosci


Background: Central fever was considered a poor prognostic factor in patients with intracerebral haemorrhage and is associated with increased mortality rates and poor outcomes. Objective: To determine the effect of fever on the neurologic outcomes of patients with intracerebral haemorrhage.

Methods: This is an observational cross-sectional study using probability sampling. A sample size of 323 yielded a 95% CI with a 5% margin of error. Data were analyzed using descriptive statistics. The relationship between the location and volume of the haemorrhage with the outcome of patients who developed central fever was determined using ANOVA. P-value was set at ≤0.01.

Results: Twenty eight percent had infectious fever while the remaining 72% had a central cause. 99 patients had severe strokes involving the basal ganglia (39%) followed by the thalamus (23%). Using ANOVA, a statistically significant relationship existed between hemorrhage involving the pons (p value=0.001) and basal ganglia (p value=0.001). The relationship between poor neurologic outcome with that of a ≥30cc haemorrhage (p value=0.000) or a bleed of <30cc (p value=0.000) were both statistically significant. There is also a significant relationship between poor outcomes among those with central fever with (p value=0.000) or without (p value=0.000) intraventricular involvement.

Conclusion: Central fever negatively impacts outcome in pontine and basal ganglia haemorrhages within the 24, 48 and 72 hours upon admission. Central fever also leads to poor neurologic outcome regardless of intraventricular involvement and volume of the haemorrhage.

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