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Influence of topography of porous-Nurses A phase bioceramic on metabolic activity of adult human mesenchymal stem cells

Joint Event On World Congress on Novel Trends and Advances in Biotechnology, Cell & Stem Cell Research & 15th Annual Congress on Pediatrics
November 28-29, 2018 Barcelona, Spain

Ruben Rabadan-Ros, Clara Meseguer-Ortiz, Belen Gil-Munoz, JI Pena, Lorena Grima , Luis Meseguer-Olmoand and Dra Piedad N de Aza

Catholic University of Saint Anthony, Spain Morales Meseguer University Hospital, Spain Mesa del Castillo Hospital, Spain Zaragoza University-CSIC, Spain Miguel Hern├?┬índez University, Spain

Posters & Accepted Abstracts: Arch Med

Abstract:

It is well known that Si-Ca-P bioceramics are promising bioactive materials for bone tissue engineering, particularly for bone repair1. Silicon incorporation to these ceramics may be fundamental to skeletal development stimulating mesenchymal stem cells proliferation and differentiation to osteoblasts 2,3. An important characteristic of a bioceramic designed for bone reconstruction is its open porosity with a high area / volume ratio that facilitates the initial circulation of biological fluids, cell migration and vascular invasion after bone implantation 4,5. In this work, we have processed a Si-Ca-P ceramic using a Q-switched Nd:YAG laser, obtaining biocompatible ceramics with 70 μm and 350 μm homogeneously distributed interconnected pores. In vitro assays using ahMSCs showed that cells seeded onto the top of these scaffolds could proliferate, cross the small pores and enter into big pores. So, if we use these bioceramics in vivo, we could probably observe how the cells penetrate into the bioceramics through the pores, improving the cellular and vascular colonization of the biomaterial and allowing initial circulation of the body fluids from the first moment of implantation, increasing the bioceramic biodegradability.

Biography :

Ruben Rabadan (PhD) is a post-doctoral researcher who has his expertise in Tissue Repair, and passion in improving the health by the study of Organ and Tisse Regeneration. In his short career, he has focused in bone, ligament and cartilage regeneration, and he has helped to develop scaffolds based on the C2S-TCP phase diagram and combinating bioceramics with fibroin, specially testing their biocompatibility and osteointegration by in vitro and in vivo studies.

E-mail: [email protected]