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Archives of Clinical Microbiology

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Investigation of therapeutic potential of Cytokine IL-33 in hepatitis

4th International Conference on Digital Pathology
August 22-23, 2019 Zurich, Switzerland

Tariq Munir

Pakistan

Posters & Accepted Abstracts: Arch Clin Microbiol

Abstract:

A new member cytokine IL-33 has recently joined the family of IL-1 because of its 11th number in the family it is also nominated as IL-1F11. In human and mice, main source of IL-33 is liver fibrotic cells and Hepatic stellate cells (HSC) when are in their activated form. To explore the functional role of IL-33 in viral related liver pathology, murine model of hepatitis was developed by injecting Poly I:C and hepatoprotective function of IL-33 was by administration of pre-treatment of mice with recombinant IL-33 (rIL-33). The poly I:C represents a relevant viral hepatitis model in human, because poly I:C is a virus-related dsRNA mimetic which plays role in increasing the IL-33 level in fulminant hepatitis. The poly I:C activates the NK cells in liver that leads to induction of inflammation. The present proposal was to decode the hepatoprotective role of IL-33 and underlying mechanism in viral dsRNA mimetic and poly I:C mediated acute liver diseases i.e. Hepatitis in murine model. Serum biochemical parameters like dosage of aspartate aminotransferase (AST), alanine aminotransferase (ALT) was carried out by diagnostic kit in biochemistry autoanalyzer that displayed in higher amount in those mice that were challenged with Poly I:C and their level was observed lower in post-treated rIL-33 group after Poly I:C administration and the quantitative measurement of serum INF-γ and TNF-α was performed using Albcam’s INF-γ and TNF-α mice ELISA kits results of both these pro-inflammatory cytokines were same like ALT/AST. Level of these cytokines was also higher in Poly I:C challenged group and lower in post-treated rIL-33 group. These results confirmed the therapeutic effect of IL-33 in hepatitis or liver related diseases. The results were statistically analyzed by T test and one way ANOVA that proven the level of liver biomarkers and pro-inflammatory were significantly differ in rIL-33 treated mice trials.

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