International Journal of Drug Development and Research

  • ISSN: 0975-9344
  • Journal h-index: 51
  • Journal CiteScore: 46.50
  • Journal Impact Factor: 26.99
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
Indexed In
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Scimago
  • Directory of Research Journal Indexing (DRJI)
  • OCLC- WorldCat
  • Publons
  • MIAR
  • University Grants Commission
  • Euro Pub
  • Google Scholar
  • J-Gate
  • Secret Search Engine Labs
  • ResearchGate
  • International Committee of Medical Journal Editors (ICMJE)
Share This Page

Ocular Delivery of Itraconazole-loaded Proniosomal Gels for Effective Control of Ocular Keratitis

Proceedings of Formulations 2021 & Pharmacovigilance 2021
September 15-16, 2021 WEBINAR

Nermin E. Eleraky*, Ayat Allam, Hesham M. Tawfeek, Mohamed A. El-Mokhtar

Assiut University, Egypt

Posters & Accepted Abstracts: Int J Drug Dev & Res


Fungal keratitis is the prime cause of ophthalmic mycosis that leads to corneal scarring and vision loss. The unique defensive mechanisms of the eye result in inadequate corneal permeability. Besides, frequent administration of conventional dosage forms may lead to patient incompliance and failure of treatment. The current study focuses on the development of proniosomal gel formulation as a drug carrier to enhance the ocular availability and antimycotic activity of itraconazole for the management of keratitis. Proniosomal gels were prepared using the coacervation phase separation method according to a 32factorial design. The formed gels were homogenous, mucoadhesive, and spreadable. After hydration of proniosomal gels, the resulting niosomes were evaluated in terms of vesicle size, size distribution, surface charge, and encapsulation efficiency. The optimized proniosomal gel comprised of Span® 40 (1800 mg), lecithin (900 mg), and cholesterol (280.7 mg), displayed particle size of 289.567±5.1 nm, PDI of 0.5, the zeta potential of -22.033 ± 1.98 mV, and encapsulation efficiency of 96.9 ± 1.5%. The in vitro antimycotic study revealed a significant increase in the zone of inhibition of Candida albicans culture for the optimized proniosomal gel relative to free itraconazole dispersion. The in vivo antifungal activity was evaluated using an animal model of rabbits’ eyes infected with Candida albicans. Proniosomal gel-treated animals; showed a significant reduction in Candida counts at the days 8 and 12 post-infection compared to free drug dispersion. Hence, the developed proniosomal gel system might provide a promising carrier for ophthalmic drug delivery and improved management of ocular keratitis.

Biography :

Nermin E. Eleraky has completed her PhD at the age of 33 years from Cincinnati University and postdoctoral studies from Assiut University School of Pharmacy. She is a lecturer in Faculty of Pharmacy, Assiut University, Egypt. She has published 12 papers in reputed journals and has been serving as a reviewer in respective journals.