Flyer

Journal of Neurology and Neuroscience

  • ISSN: 2171-6625
  • Journal h-index: 15
  • Journal CiteScore: 2.13
  • Journal Impact Factor: 1.45
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
20+ Million Readerbase
Indexed In
  • Open J Gate
  • Genamics JournalSeek
  • The Global Impact Factor (GIF)
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • OCLC- WorldCat
  • Proquest Summons
  • Scientific Journal Impact Factor (SJIF)
  • Euro Pub
  • Google Scholar
  • Secret Search Engine Labs
Share This Page

Prognostic values of peripheral glutamate and TNF levels in patients with intracerebral haemorrhage

International Conference on Neurological Disorders, Stroke and CNS
October 22-23, 2018 Athens, Greece

Vladimir Rendevski, Boris Aleksovski and Mihajlovska Rendevska

Saints Cyril and Methodius University of Skopje, Macedonia

Posters & Accepted Abstracts: J Neurol Neurosci

Abstract:

Intracerebral hemorrhage (ICH), a detrimental disease, is associated with one month fatality in 40% of patients and worst neurological outcome among survivors. In the past several years, emerging evidence suggests that inflammatory and excitotoxic mechanisms are in the core of the pathophysiological processes, leading to neurological deterioration and secondary brain injury after ICH, thus being tied up to the patient’s outcome. Following ICH, tumor necrosis factor-α (TNF-α) signalling exerts an acute detrimental role, being also argued as the main driver for increase in the blood brain barrier permeability and formation of the perihematomal edema. Elevated perihematomal glutamateinduced excitotoxicity have also been associated with the blood brain barrier disruption and neuronal death, severely affecting patient prognosis. In this lecture, we discuss the results from our working group which support the idea that peripheral TNF-α and glutamate levels can reflect CNS inflammation and excitotoxicity following ICH, as well as their utility as biomarkers for prognostication and clinical decision making between conservative or surgical treatment in patients with ICH.

Biography :

E-mail:

[email protected]