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Journal of Neurology and Neuroscience

  • ISSN: 2171-6625
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Journal of Neurology and Neuroscience received 1528 citations as per Google Scholar report

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Retinal thickness in Alzheimer’s disease: A systematic review and meta-analysis

Joint Event on 28th International Conference on Neuroscience and Neurochemistry & 28th Euro-Global Neurologists Meeting
June 13-14, 2019 Barcelona, Spain

Shabbir Saifuddin

University of Dubai, UAE

Posters & Accepted Abstracts: J Neurol Neurosci

Abstract:

Introduction: Retinal characteristics are increasingly recognized as biomarkers for neurodegenerative diseases. Retinal thickness measured by optical coherence tomography may reflect the presence of Alzheimer’s disease (AD). We performed a meta-analysis on retinal thickness in AD and mild cognitive impairment (MCI) patients and healthy controls (HCs).

Methods: We selected 25 studies with measurements of retinal thickness including 887 AD patients, 216 MCI patients, and 864 HCs that measured retinal thickness. Outcomes were peripapillary retinal nerve fiber layer (RNFL) and macular thickness. The main outcome was the standardized mean differences (SMDs). We used STATA to perform the meta-analysis (StataCorp, Texas; version 14.0).

Results: Relative to HCs, AD and MCI patients had lower peripapillary RNFL (SMD 0.98 [CI −1.30, −0.66, P < .0001] and SMD 0.71 [CI −1.24, −0.19, P = .008]). Total macular thickness was decreased in AD patients (SMD 0.88 [CI −1.12, −0.65, P = .000]).

Discussion: Retinal thickness is decreased in AD and MCI patients compared to HC. This confirms that neurodegenerative diseases may be reflected by retinal changes.

Keywords: Meta-analysis, Optical coherence tomography (OCT), Retinal thickness, Eye, Biomarkers, Alzheimer’s disease (AD), Mild cognitive impairment (MCI)

Biography :

E-mail: tasmooon@gmail.com

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