Tannaz Dehpouri, Zahra Bagherzadegan, Faezeh Kohansal and Ebrahim Salehifar
Imam Khomeini Hospital, Iran
Mazandaran University of Medical Sciences, Iran
Posters & Accepted Abstracts: Arch Med
Introduction: The indiscrimmate use of board spectrum antibiotics is a universal dilemma. This study was done to evaluate the Imipenem usage in different parts of Imam Khomeini Hospital in Sari.
Methods: This study was conducted in Imam Khomeini teaching hospital, affiliated to Mazandaran University of Medical Sciences in North of Iran. The use of imipenem before and after implementation of national guidelines for rational use of costly antibiotics (2016 versus 2018) has been evaluated. Health Information System (HIS) was used to extract the days patients stayed in the hospital and also the Defined Daily Dose (DDD) which recommended by World Health Organization (WHO) as an identical measurement of use of drugs.
Results and Discussion: Total Hospitalized patients were 110262 and 105412 in 2016 and 2018, respectively. Calculations show that the DDD values of Imipenem were 5.75 and 4.75 in 2016 and 2018, respectively. The DDD values of different wards in 2016 and 2018 were as following: Neurosurgery (1.08 to 0.52), ICU (6.67 to 4.33), Vascular surgery (102.40 to 45.83), Gynecology (0.14 to 0.04), Emergency (7.94 to 5.27), Oncology (19.61 to 13.25), Surgery ward (3.19 to 1.51), Gastroenterology (4.19 to 3.57), Oncosurgery (244.12 to 131.23). Showed that DDD values reduced in 2018 Comparing to 2016. The DDD values of some wards including Internal ward (12.07 to12.21), Orthopedy (2.53 to 11.01), Orology (2.04 to 2.64) were increased in 2018 compared to 2016. The highest rate of DDD in 2016 and 2018 were both for for Oncosurgery (244.12 and 131.21, respectively) and the lowest value were for Gynecology (0.14 and 0.04, respectively).
Conclusion: This study showed that implementation of rational prescribing protocol for administration of Imipenem effectively decreased the DDD and consequently lowerd the cost of this valuable antibiotic., in different wards affected positivelyon antibiotic usage rate, decrease of expenditure from 2972880000 to1323520000Rial and DDD value from 5.75 to 4.75.