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The aim of the present study was to determine the sensitivity of Aeromonas hydrophila to dis-infectants and to propose an efficient method for control of fish diseases caused by this patho-gen The tested A. hydrophila strains were inactivated by the combinations of glutaraldehyde, formaldehyde and quaternary ammonium salts (HMI® Glicofin) and glutaraldehyde, (ethylene-dioxy) dimethanol and benzalkonium chloride (Aldesept®). Iodine (Desinfekt B®), n-alkyl-dimethyl-benzyl-ammonium chloride (HMI® Roda Super), ethanol (40%, 50% and 70%) and potassium permanganate (1000 mg/l) were also found effective against A. hydrophila. At a concentration of 5 mg/L, potassium permanganate reduced A. hydrophila (?TCC 7965) counts by 3% (log10 0.25), while the strain was completely inactivated by 100 mg/L. Under the influ-ence of 5 mg/L and 100 mg/L potassium permanganate, the clinical A. hydrophila isolate counts were reduced by 0.7% (log10 0.06), and 2.3% (log10 0.19), respectively. Most tested disinfectants were effective against A. hydrophila, with the exception of potassium permanga-nate at 5 mg/L.