Background: Coagulase-positive S. aureus is among the most ubiquitous and dangerous human Pathogens, for both its virulence and its ability to develop antibiotic resistance. Development of Antimicrobial resistance has limited treatment options against infections due to this pathogen. The aim of this study was to assess the Antimicrobial agent’s susceptibility of coagulase-positive S. aureus isolated from patients admitted at Tikur Anbessa specialized hospital, Addis Ababa Ethiopia
Methods: The study was part of a cross sectional study conducted among 413 admitted patients Suspected of HAI to assess the prevalence of Staphylococcus aureus and associated risk factors. Participants were recruited using consecutive convenient sampling technique. Antimicrobial Agents susceptibility were tested on (n=160) coagulase positive S. aureus and (n=57) MRSA Isolates to panels of 9 antimicrobial agents using disc diffusion assay QC was performed to Check the quality of medium. Each new lot was quality controlled before use for testing the Staphylococcus aurous using standard strains (ATCC25923). Collected data were entered and analysed using SPSS version 24.
Result: From the total Coagulase positive S. aureus’s (n=160), 142(88.8%) isolates were Resistant to Penicillin 143(89.4%) followed by Erythromycin 93(58.1%), Gentamicin 87(54.4%), Ciprofloxacin 89(55.6%), Cefoxitin 57(35.6%), Trimethoprim Sulfamethoxazole 69(43.1%), Clindamycin 9(5.6%), ceftriaxone and Augmentin each 37(35.6%). All 57 MRSA strains were 100% resistant to Penicillin, Erythromycin, Augmentin, Cefoxitin and Ceftriaxone. Whereas 9 (15.8%) were resistant to Clindamycin, 37 (65%) to Trimethoprim sulfamexozole, 52 (91.2%) to Gentamycin and 46 (80.7%) to Ciprofloxaci 47
Conclusion: Multiple drug resistance of S. aureus isolates to antimicrobials was alarmingly high so that any empirical prophylaxis and treatment needs careful selection of effective drugs.
Published Date: 2022-02-21; Received Date: 2021-12-08