Molecular Enzymology and Drug Targets

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By Preventing -Glucosidase and -Amylase Noncompetitively, Phenols from Sterculia Nobilis Smith Pericarp In-Products Postpone the Digestion of Carbohydrates

Pooja Bhatiya*

The functional activity and phytochemical makeup of Sterculia Nobilis Smith pericarp, a byproduct of this tropical and subtropical fruit, have not received much attention. The LC-ESIMS/MS-MRM technique was employed in this study to analyse 16 phenolic compounds in the ethyl acetate fraction of the Sterculia Nobilis Smith pericarp extract on a qualitative and quantitative level. The main phenolic in the EAF were luteolin-7-O-glucoside, epicatechin gallate, and apigetrin. Models of inhibition of -glucosidase and -amylase were used to investigate the hypoglycemic action of EAF. With half-inhibitory concentration levels, EAF inhibited -glucosidase and -amylase activities in a reversible and non-competitive manner. The EAF's enzyme inhibition mechanism was investigated using spectroscopic techniques. The outcomes demonstrated that EAF changed the secondary structure and microenvironment of the enzymes' tyrosine and tryptophan residues. This study shows that the pericarp of Sterculia Nobilis Smith can be used as a low-cost raw material for the manufacturing of functional meals. Internal organ damage brought on by hyperglycemia can result in heart attacks, kidney failure, stroke, blindness, and kidney failure. As a result, diabetes has grown to be a serious hazard to human health and must be treated with long-term usage of hypoglycemic medications. These medications do have negative effects, though; include weight gain, upper respiratory tract infections, hypoglycemia, and gastrointestinal issues.


Sterculia Nobilis Smith Pericarp; Phenolics; A-Glucosidase; A-Amylase; Postprandial Hyperglycemia

Published Date: 2023-04-28; Received Date: 2023-04-03