Kingston Imperial Institute of Technology and Science, India
Short Communication
A smart innovative approach for delivery of nanosized risperidone to brain via novelistic trans vermillion route
Author(s): N V Satheesh Madhav* and Bhavana Singh
Aim:
Performance evaluation of Risperidone loaded bio-flexi films using Cucurbita pepo.
Research design and Methods:
The risperidone loaded bio-flexi films was prepared using novel bio-film former isolated from fruit pulp of Cucurbita pepo by solvent casting method with different ratios (1%, 2%, 3%, 4%, 5% and 8%) and with standard polymer HPMC and CMC-Na (1%, 2%, 3%, 4% and 5%). The prepared formulations were evaluated for thickness, folding endurance, swelling index, content uniformity, in-vitro drug release, scanning electron microscopy (SEM), transmission electron microscopy (TEM), invitro cytotoxicity and stability studies.
Results:
The best formulation shows an R2 value of 0.9814, T50% of 29.7 hrs and T80% of 65.25 hrs respectively. According to the release kinetics the best fit.. View More»
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