Department of Chemical Science, Olusegun Agagu University of Science and Technology, Ondo State, Nigeria
Research Article
COMPARATIVE α-AMYLASE AND α-GLUCOSIDASE INHIBITORY POTENCY AND MODE OF INHIBITION OF AQUEOUS LEAF EXTRACTS OF Acalypha wilkesiana �??green�?? AND Acalypha wilkesiana �??red�??
Author(s): Didunyemi OM*
The objective of this study was to investigate comparatively the inhibitory potency and mode of inhibition of aqueous leaf extracts of Acalypha wilkesiana ‘green’ (A.w.g) and Acalypha wilkesiana ‘red’ (A.w.r) on alpha glucosidase from Saccharomyces cerevisiae and alpha amylase from Aspergillus oryzae with a view to establishing the better antidiabetic plant. This study employed para-nitrophenylglucopyranoside (PNPG) and starch as substrates while Acarbose was used as reference. We also qualitatively screened for important phytochemicals as well as the phenolic contents of the extracts. The extracts contained alkaloid, flavonoid, saponin, tannin, steroid, carotenoid and terpenoid while anthraquinone was absent. Aqueous extract of A.w.r had the higher total phenolics (total phenol: 35.75±3.39mgGAE/g and total flavonoid: 350.63±5.01mgQE/g). A.w.r exp.. View More»
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