Department of Neurosciences, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil, Brasil
Research Article
GABA levels decrease in brain areas associated with neurodegeneration in Alzheimer's and Parkinson's diseases: Systematic review and meta analysis
Author(s): Flavio M. Morais, Pollyanna V.G. Silva and Angela M. Ribeiro*
Background: Data obtained by our group and by other authors directed our interest towards better understanding the involvement of the GABArgic and glutamatergic systems in the neurodegenerative process. We began a more in-depth search into this subject and came across various apparently contradictory data, most likely from the use of different experimental models and measurement conditions. We therefore considered it relevant to carry out a systematic review followed by a meta-analysis of the results, with the aim of answering contradictory questions about the involvement and importance of components of these two systems in the neurodegeneration process associated with AD and PD. There is no systematic survey in the literature aimed at verifying the relevance and degree of significance of the relationships between GABAergic and glutamatergic parameters and the neurode.. View More»
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