Farmacologia y Toxicologia

  • ISSN: 2174-8365
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Max Planck

Department of pharmacological evaluation and toxicology, Brazil

  • Mini Review   
    Forsythia?s pharmacological evaluation and genetic toxicology
    Author(s): Max Planck* and Banjamen babrare

    The primary component of Forsythia suspense, forsythin, is therapeutically used to treat fever, viral colds, gonorrhoea, and ulcers. The objective of this study was to assess the safety of forsythin for human use as well as any potential genetic harm. The Ames test, chromosomal aberration (CA) test, and bone marrow micronucleus (MN) test were used to evaluate the genetic toxicity of forsythin in vivo in accordance with GLP standards and test guidelines. In the Ames test, the number of His + revertant colonies was counted after five Salmonella typhimurium strains were subjected to varying forsythin concentrations in the presence or absence of the S9 mixture. In the CA test, chromosomal abnormalities were identified after treating Chinese hamster lung (CHL) fibroblast cells with various concentrations of forsythin, mitomycin C, or cyclophosphamide in the presence or absence of the S9 mi.. View More»

    DOI: 10.36648/2174-8365.12.4.117

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