Department of pharmacodynamics, Delhi university, China
Research Article
Chinese patients suffering from renal impairment: a cardiopulmonary exercise toxicokinetic concept.
Author(s): Nicholas L. Mills*
To create preliminary physiologically based population models for Chinese patients with renal impairment and to assess the performance of new population models in predicting the effects of antibacterials cleared by the kidney. Chinese renal impairment patients' demographic information and physiological parameters were first gathered, and new population models were then built by recalibrating the relative demographic and physiological equation's coefficients. Second, Caucasian renal impairment population models created in Simcyp, Chinese healthy volunteers, and Caucasian healthy volunteers gathered and verified drugindependent parameters of ceftazidime, cefodizime, vancomycin, and cefuroxime. Finally, four antibacterial medication plasma concentrations in Chinese patients with renal impairment were predicted using the newly built demographic models. The primary pharmacokinetic .. View More»
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