Department of Science, Center of Research, Germany
Mini Review
Optimized antifungal and antibiotic activities of nanoparticles entrapped in antibody octominin
Author(s): Raksha T*
The nanoencapsulation of antimicrobial peptides (AMPs) has been utilized as a
strategy to overcome obstacles such as poor stability, adverse interactions, and
toxicity. Antimicrobial peptides (AMPs) have emerged as an essential solution
for controlling multi-drug-resistant (MDR) pathogens. Octominin's potent
antimicrobial activity against Candida albicans and Acinetobacter baumannii
has been demonstrated in previous research. The ionotropic gelation method is
the focus of this study, which focuses on the nanoencapsulation of Octominin
using chitosan (CS) and carboxymethyl chitosan (CMC) as drug delivery systems.
Octominin-encapsulated CS nanoparticles (Octominin-CNPs) had a zeta potential
of +51.23 0.38 mV and an average diameter of 372.80 2.31 nm, respectively.
Encapsulation efficiency was 96.49 percent, and loading capacity was 40.20
percent. Further.. View More»
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