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Farmacologia y Toxicologia

  • ISSN: 2174-8365
  • Journal h-index: 1
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
Indexed In
  • OCLC- WorldCat
  • Euro Pub
  • SHERPA ROMEO
  • International Committee of Medical Journal Editors (ICMJE)
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Richard Adams

Health science and medicine Karolinska Institute, Sweden

Publications
  • Short Communication   
    Paracetamol?s Hepatic Pharmacology and Toxicology: Age-Related Changes
    Author(s): Richard Adams* and Jhoseph advar

    When the pharmacokinetics and pharmacodynamics of the medicine are known, the best course of treatment can be chosen. However, choosing the best dose for an older adult might be difficult due to age-related changes in pharmacokinetics and pharmacodynamics, as well as the increased interindividual variance. Suboptimal dose selection, subpar efficacy, and/or increased toxicity are caused by a lack of knowledge about how hepatic clearance and toxicity change with age. The analgesic paracetamol, which has been around for more than 50 years and is frequently ingested by elderly persons, is of special concern. Although paracetamol is generally regarded as a safe medicine, care must be exercised due to its potential for toxicity. Up to 55% of elderly persons who accidentally overdose on paracetamol experience liver damage. A better understanding of how ageing impacts medication toxicity and .. View More»

    DOI: 10.36648/2174-8365.12.4.119

    Abstract HTML PDF