Department of Emergency Medicine, University of Amsterdam, Netherlands
Review
Photoinitiated Copolymerization Provides For the Quick Creation of Geometric Sulfobetaine Vinylimidazole-Based Monoliths for Hydrophilic Interaction Chromatography
Author(s): Vijay Yadav*
Hydrophilic interaction chromatography has increased interest in zwitterionic sulfobetaine-based monolithic stationary phases. Using methanol and tetrahydrofuran as the porogenic system, a new hydrophilic polymeric monolith was created in this study by photo-initiated copolymerization using pentaerythritol triacrylate. It is noteworthy that the time needed to construct this unique monolith was only 5 min, which was much less time than was needed to prepare previously described sulfobetaine-based monoliths using traditional thermally started copolymerization. Additionally, the shape, permeability, porosity, mechanical strength column efficiency, and repeatability of these monoliths were all good. Mechanistic studies suggested that the retention of polar analytes on the zwitterionic SBVI-based monolith may be caused by potent hydrophilic and electrostatic interactions. The resultant mon.. View More»
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