Spanish Chinese Russian German French Japanese Portuguese Hindi Telugu Tamil
Flyer

Health Science Journal

  • ISSN: 1108-7366
  • Journal h-index: 51
  • Journal CiteScore: 10.69
  • Journal Impact Factor: 9.13
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
Google Scholar citation report
Citations : 12326

Health Science Journal received 12326 citations as per Google Scholar report

Flyer image
Indexed In
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • CINAHL Complete
  • Scimago
  • Electronic Journals Library
  • Directory of Research Journal Indexing (DRJI)
  • EMCare
  • OCLC- WorldCat
  • University Grants Commission
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
  • Google Scholar
  • SHERPA ROMEO
  • Secret Search Engine Labs
View More
Share This Page

Advanced Polytherapy of Severe Ulcerative Colitis in an Elderly Patient: a Case

XX Congresso Regionale FADOI CAMPANIA: Non ci siamo mai fermati
Italy 2021

Magro VM and Caturano M

Department of Internal Medicine and Geriatrics, University of Campania â�?�?Luigi Vanvitelliâ�?, Naples, Italy
Department of Internal Medicine, AORN San Giovanni di Dio and Ruggi d��?Aragona, Salerno, Italy

Posters & Accepted Abstracts: Health Sci J

Abstract:

Background: Ulcerative colitis represents a challenge for the clinician, although there are numerous therapeutic protocols applicable to difficult cases. We present a case report. Case history: An 84-year-old patient, suffering from ulcerative colitis, already treated surgically (colectomy with ileorectum anastomosis), had crises of colitic-like pain with very high inflammatory indices despite steroid therapy. A rectosigmoidoscopy revealed serpiginous ulcers in the ileal mucosa, with a more severe picture in the pre-anastomotic site. At the ileo-rectal level, the mucosa was intensely hyperemic, inflamed and eroded. We started mesalazine 3 g, aminosalicylic acid 2 g, ciprofloxacin 1 g, attempting a corticosteroid downtitration. However, a subsequent colonoscopic examination after one month revealed that the ileorectal anastomosis appeared stenotic with deep ulcers and the rectal mucosa appeared hyperemic and subatrophic with more mold ulcers. We opted for prolonged release beclomethasone dipropionate and adalimumab (160 mg at week 0, 80 mg at week 2, 40 mg at weeks 4 and 6), with good resolution of symptoms, decrease in inflammatory indices, waiting for the new endoscopy. Discussion: We described a multi-therapeutic approach using monoclonal antibody that ensured a good decrease in symptoms with a satisfactory quality of life in an elderly patient with severe disease. References 1. Sandborn WJ, van Assche G, Reinisch W, Colombel JF, D'Haens G, et al. (2012) Adalimumab induces and maintains clinical remission in patients with moderate-to-severe ulcerative colitis. Gastroenterology 142: 257-265.e1-3. 2. Reinisch W, Sandborn WJ, Hommes DW, et al. (2011) Adalimumab for induction of clinical remission in moderately to severely active ulcerative colitis: results of a randomised controlled trial. Gut 60: 780-781.

PDF HTML