Flyer

Health Science Journal

  • ISSN: 1108-7366
  • Journal h-index: 61
  • Journal CiteScore: 17.30
  • Journal Impact Factor: 18.23
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Awards Nomination 20+ Million Readerbase
Indexed In
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • CINAHL Complete
  • Scimago
  • Electronic Journals Library
  • Directory of Research Journal Indexing (DRJI)
  • EMCare
  • OCLC- WorldCat
  • University Grants Commission
  • Geneva Foundation for Medical Education and Research
  • Euro Pub
  • Google Scholar
  • SHERPA ROMEO
  • Secret Search Engine Labs
Share This Page

Synthesis, biological activity and DFT studies of new hydropyrimidine compounds

World Medical Conference on EYE AND VISION & WORLD PHARMACEUTICAL SCIENCES & DRUG DELIVERY & EURO MICROBIOLOGY & NOVEL CORONA VIRUS DISEASES
August 26-27,2021 Webinar

Maria Marinescu, Claudia-Valentina Popa, Ludmila Otilia Cinteza, Christina-Marie Zalaru

Department of Organic Chemistry, Biochemistry and Catalysis, Faculty of Chemistry
University of Bucharest, Romania, Europe.

Scientific Tracks Abstracts: Health Sci J

Abstract:

A series of the dihydropyrimidinones was obtained by the Biginelli condensation using ZnO nanoparticles as catalyst. A new series of compounds was obtained by alkylation of the dihydropyrimidinones with different halogenated compounds (Fig. 1). The structures of all compounds were confirmed by 1H, 13C-NMR, FTIR, UV-VIS spectra and elemental analysis. All derivatives were evaluated by qualitative and quantitative methods against a panel of selected bacterial and fungal strains. A DFT analysis of molecular structure and frontier molecular orbitals HOMO-LUMO was performed using the GAMESS 2012 software. Antimicrobial activity of the synthesized compounds (Fig. 2) was corelated with electronic parameters (chemical hardness, electronic chemical potential, global electrophilicity index), Mullikan atomic charges and geometric parameters of the tetrahydropyrimidines calculated with GAMESS. It has been found that the presence of nucleophilic group and the symmetry of the molecule are advantages for a high antimicrobial activity.

Biography :

Maria Marinescu has completed his PhD from University of Bucharest. He is Assistant Professor in the department of Organic Chemistry, Biochemistry and Catalysis, a premier research organization. He has published more than 30 papers in reputed journals.