Department of Biochemistry, University of Dschang, Research Unit of Microbiology and Antimicrobial Substances, P.O Box 96 Dschang, Cameroon
Research Article
Pulmonary Tuberculosis and Diabetes Comorbidity is Associated with Systemic Raising of Th1, Th17 and Other Biochemical Parameters
Author(s): Leonard Fonkeng Sama*, Thibau Flaurant Tchouangueu, Omer Bebe Ngouateu, Salomon Bonsi Tchuandom, Ousenu Karimo and Christopher B Tume
Background: This study aims to assess the impact of type 2 diabetes on pulmonary tuberculosis immune response.
Methods: Diagnosis of tuberculosis was based on positivity on the sputum smear and culture, whereas type 2 diabetes was diagnosed based on fasting blood sugar, 2-h Plasma Glucose (PG), oxidative method and glycated haemoglobin. Standardized techniques were used to obtain liver enzymes and lipid profiles, whereas ELISA cytokine assay system was used to measured plasma cytokines levels.
Results: Significantly higher levels of fasting blood glucose (p<0.0001), 2-hPG (p=0.0097) and percentage of glycated haemoglobin (p<0.0001) were found in TB patients with diabetes as compared with TB patients without diabetes (p<0.05). Regarding lipid profile, higher total cholesterol (p=0.0093), serum triglycerides.. View More»
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