Department of Neurology, Max Hospital Saket, New Delhi, India
Case Report
ISAAC syndrome
Author(s): Sumeet Swapan Roy*, Raghav Kapoor, Rahul Saini and Nikita Goel
ISSAC Syndrome is a form of peripheral nerve hyperexcitability
caused by continuous muscle fiber activity. The patient usually
presents with the complaints of twitching and stiffness. Symptoms
such as myokymia and muscle spasm, may persist during sleep.
The patients are reported to be CASPR2 antibody positive which
is ought to be the pathogenic antibody in ISSAC Syndrome. The
patients are commonly treated with immunomodulatory therapies
which includes steroids, plasma exchange therapy and rituximab
for nonresponsive cases. Treatment also includes symptomatic
management which has no effect on disease progression.
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